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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Citarinostat
Citarinostat

Chemical Structure : Citarinostat

CAS No.: 1316215-12-9

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Citarinostat (ACY-241, ACY241)

货号: PC-20984Not For Human Use, Lab Use Only.

Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM.

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5 mg (Free Sample) ￥180 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM.
Carinostat (ACY-241) inhibits HDAC1, HDAC2, HDAC3 and HDAC8 with IC50 of 35 nM, 45 nM, 46 nM and 137 nM, respectively.
Carinostat (ACY-241) enhances the activity of paclitaxel in solid tumor models.
Combination ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma.

物理化学性质&存储条件

分子量 467.95
分子式 C24H26ClN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide

参考文献

1. Huang P, et al. Oncotarget. 2017 Jan 10;8(2):2694-2707.

2. Awad MM, et al. Front Oncol. 2021 Sep 6;11:696512.

3. Ray A, et al. Leukemia. 2018 Mar;32(3):843-846.

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