Cipemastat |CAS:190648-49-8 Probechem Biochemicals

Chemical Structure : Cipemastat

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Cipemastat (Ro 32-3555, Ro32-3555)

货号: PC-62945Not For Human Use, Lab Use Only.

Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9).

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生物&药学活性

Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9).
Cipemastat (Ro 32-3555) inhibits human collagenases 1, 2 and 3 (Ki of 3.0, 4.4 and 3.4 nM), and Ro 323555 is a selective inhibitor of collagenases over the related stromelysin 1, and gelatinases A and B (Ki of 527, 154 and 59 nM).
Cipemastat (Ro 32-3555) prevents cartilage breakdown both in vitro and in vivo.

物理化学性质&存储条件

分子量	436.553
分子式	C22H36N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(αR,βR)-β-(CyclopentylMethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-triMethyl-2,5-dioxo-1-iMidazolidinyl)Methyl]-1-piperidinebutanaMide

参考文献

1. Lewis EJ, et al. Br J Pharmacol. 1997 Jun;121(3):540-6.

2. Whittaker M, et al. Chem Rev. 1999 Sep 8;99(9):2735-76.

3. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8.

4. Brewster M, et al. Arthritis Rheum. 1998 Sep;41(9):1639-44.

Cipemastat (Ro 32-3555, Ro32-3555)

生物&药学活性

物理化学性质&存储条件

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Cipemastat (Ro 32-3555, Ro32-3555)

生物&药学活性

物理化学性质&存储条件

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