Ciluprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Ciluprevir

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Ciluprevir (BILN2061, BILN 2061)

货号: PC-35056Not For Human Use, Lab Use Only.

Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively.

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生物&药学活性

Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively.
Ciluprevir inhibits the replication of HCV replicon 1b and 1a with IC50 of 3 nM and 4 nM, respectively.

物理化学性质&存储条件

分子量	774.934
分子式	C40H50N6O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,6S,13aS,14aR,16aS,Z)-6-(((cyclopentyloxy)carbonyl)amino)-2-((2-(2-(isopropylamino)thiazol-4-yl)-7-methoxyquinolin-4-yl)oxy)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-car

参考文献

1. Lamarre D, et al. Nature. 2003 Nov 13;426(6963):186-9.

2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14.

3. Llinàs-Brunet M, et al. J Med Chem. 2004 Mar 25;47(7):1605-8.

4. Thibeault D, et al. J Virol. 2004 Jul;78(14):7352-9.

Ciluprevir (BILN2061, BILN 2061)

生物&药学活性

物理化学性质&存储条件

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Ciluprevir (BILN2061, BILN 2061)

生物&药学活性

物理化学性质&存储条件

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