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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Cilostazol
Cilostazol

Chemical Structure : Cilostazol

CAS No.: 73963-72-1

Cilostazol (OPC 13013, OPC 21)

货号: PC-45282Not For Human Use, Lab Use Only.

Cilostazol (OPC 13013, OPC 21) is a potent, selective inhibitor of PDE3A with IC50 of 0.2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cilostazol (OPC 13013, OPC 21) is a potent, selective inhibitor of PDE3A with IC50 of 0.2 uM.
Cilostazol (OPC 13013, OPC 21) inhibits platelet aggregation and has considerable antithrombotic effects in vivo.
Cilostazol (OPC 13013, OPC 21) relaxes vascular smooth muscle and inhibits mitogenesis and migration of vascular smooth muscle cells.
Cilostazol (OPC 13013, OPC 21) also upregulates autophagy via SIRT1 activation, has preventive effects on various central nervous system (CNS) diseases.

物理化学性质&存储条件

分子量 369.4607
分子式 C20H27N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2(1H)-Quinolinone, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-

参考文献

1. Schrör K, et al. Diabetes Obes Metab. 2002 Mar;4 Suppl 2:S14-9.

2. Lee HR, et al. PLoS One. 2015 Aug 5;10(8):e0134486.

3. Qi DS, et al. Brain Res. 2016 Dec 15;1653:67-74.

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