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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Dynein-Ciliobrevin A
Ciliobrevin A

Chemical Structure : Ciliobrevin A

CAS No.: 302803-72-1

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Ciliobrevin A (HPI-4, HH pathway inhibitor 4)

货号: PC-42258Not For Human Use, Lab Use Only.

Ciliobrevin A (HPI-4) is a small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking, inhibits AAA+ ATPase motor cytoplasmic dynein.

规格 价格 库存 数量
10 mg ￥680 In stock
25 mg ￥1180 In stock
50 mg ￥1980 In stock
100 mg ￥3480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ciliobrevin A (HPI-4) is a small molecule Hedgehog pathway inhibitor (IC50=7 uM) that acts downstream of Su(fu) to modulate Gli processing, activation or trafficking, inhibits AAA+ ATPase motor cytoplasmic dynein.
Ciliobrevin does not directly target Smo, blocks the proliferation of cerebellar granule neuron precursors expressing an oncogenic form of Smo.
Ciliobrevin disrupts spindle pole assembly and kinetochore-microtubule attachment, inhibits melanosome aggregation and peroxisome motility in cultured cells.

物理化学性质&存储条件

分子量 358.1783
分子式 C17H9Cl2N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

Benzenepropanenitrile, 2,4-dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-

参考文献

1. Firestone AJ, et al. Nature. 2012 Mar 18;484(7392):125-9.

2. Hyman JM, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7.

4. Clippinger AJ, et al. Genes Dev. 2012 Sep 15;26(18):2015-26.

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