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Cilastatin sodium

Chemical Structure : Cilastatin sodium

CAS No.: 81129-83-1

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Cilastatin sodium (MK0791 sodium)

货号: PC-27654Not For Human Use, Lab Use Only.

Cilastatin sodium (MK-0791) is a reversible, competitive renal dehydropeptidase I (DPEP1) inhibitor with IC50 of 0.1 uM, also inhibits bacterial metallob-lactamase enzyme CphA, suppresses the invasion and metastasis of DPEP1-expressing cells.

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50 mg ￥580 In stock
100 mg ￥880 In stock
250 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cilastatin sodium (MK-0791) is a reversible, competitive renal dehydropeptidase I (DPEP1) inhibitor with IC50 of 0.1 uM, also inhibits bacterial metallob-lactamase enzyme CphA, suppresses the invasion and metastasis of DPEP1-expressing cells.

物理化学性质&存储条件

分子量 380.43
分子式 C16H25N2NaO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Sodium (Z)-7-(((R)-2-amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoate

参考文献

1. Moulton RD, et al. Drug Metab Dispos. 2015 May;43(5):756-61.

2. Huo X, et al. Acta Pharm Sin B. 2019 Sep;9(5):986-996.

3. Park SY, et al. Oncotarget. 2016 Feb 23;7(8):9501-12.

4. S Keynan, et al. Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31.

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