Ciforadenant |CAS:1202402-40-1 Probechem Biochemicals

Chemical Structure : Ciforadenant

CAS No.: 1202402-40-1

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Ciforadenant (CPD1110;CPI-444;V 81444)

货号: PC-61367Not For Human Use, Lab Use Only.

Ciforadenant (CPI-444, V 81444) is a potent, orally active, adenosine A2A receptor antagonist that is being investigated in solid tumors as a single agent and in combination with the anti-PD-L1 antibody atezolizumab.

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生物&药学活性

Ciforadenant (CPI-444, V 81444) is a potent, orally active, adenosine A2A receptor antagonist that is being investigated in solid tumors as a single agent and in combination with the anti-PD-L1 antibody atezolizumab.
Ciforadenant dose-dependent inhibits tumor growth in mouse model MC38.
Ciforadenant induces anti-tumor immunity in mouse tumor models and inhibits adenosine signaling in lymphocytes of treated humans.

物理化学性质&存储条件

分子量	407.434
分子式	C20H21N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine

参考文献

1. Stephen Willingham, et al. Abstract PR04: CPI-444: DOI: 10.1158/2326-6066.IMM2016-PR04 Published November 2016

Ciforadenant (CPD1110;CPI-444;V 81444)

生物&药学活性

物理化学性质&存储条件

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Ciforadenant (CPD1110;CPI-444;V 81444)

生物&药学活性

物理化学性质&存储条件

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