Chlopynostat

Chemical Structure : Chlopynostat

CAS No.:

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货号: PC-25162Not For Human Use, Lab Use Only.

Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM).

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生物&药学活性

Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM).
Chlopynostat promotes apoptosis of CLL cells by enhancing STAT4 and p66Shc expression.
Chlopynostat restores STAT4 and p66Shc expression in leukemic cells from CLL patients.
Chlopynostat promotes CLL cell apoptosis by preferentially inhibiting HDAC1.

物理化学性质&存储条件

分子量	404.85
分子式	C22H17ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Aminophenyl)-4-((7-chloro-4-oxoquinazolin-3(4H)-yl)methyl)benzamide

参考文献

1. Rossi S, et al. Biomed Pharmacother. 2024 May;174:116537.

Chlopynostat

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物理化学性质&存储条件

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Chlopynostat

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