Chemocoxib A |CAS:960214-84-0 Probechem Biochemicals

Chemical Structure : Chemocoxib A

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Chemocoxib A

货号: PC-62881Not For Human Use, Lab Use Only.

Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.

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生物&药学活性

Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.
Chemocoxib A shows no signigicant activity against COX-1, and COX-2 mutant V349L, V523I, and S530A.
Chemocoxib A exhibits cytotoxicity in cancer cell culture, inhibits the growth of human tumor xenografts in nude mice.

物理化学性质&存储条件

分子量	924.397
分子式	C49H50ClN3O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 4-[[4-[[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]butyl]amino]-4-oxo-, (5R,5aR,8aR,9R)-5,5a,6,8,8a,9-hexahydro-8-oxo-9-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-5-yl ester

参考文献

1. Uddin MJ, et al. ACS Chem Biol. 2016 Nov 18;11(11):3052-3060.

Chemocoxib A

生物&药学活性

物理化学性质&存储条件

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Chemocoxib A

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物理化学性质&存储条件

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