ChemR23 inhibitor 14f

Chemical Structure : ChemR23 inhibitor 14f

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货号: PC-72833Not For Human Use, Lab Use Only.

ChemR23 inhibitor 14f is a potent and orally active inhibitor of ChemR23 (IC80=12 nM), a G protein-coupled receptor (GPCR) expressed on the surface of plasmacytoid dendritic cells (pDCs).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ChemR23 inhibitor 14f is a potent and orally active inhibitor of ChemR23 (IC80=12 nM), a G protein-coupled receptor (GPCR) expressed on the surface of plasmacytoid dendritic cells (pDCs).
ChemR23 inhibitor 14f inhibits ChemR23 signaling through receptor internalization.
Oral administration of ChemR23 inhibitor 14f at 30 mg/kg to cynomolgus monkeys demonstrated a sustained pharmacological effect of ChemR23 internalization on pDCs.

物理化学性质&存储条件

分子量	619.755
分子式	C31H33N5O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-cyclopropyl-2-((cyclopropylmethyl)(1-(5'-methyl-2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)ethyl)amino)-N-(cyclopropylsulfonyl)thiazole-4-carboxamide

参考文献

1. Takamichi Imaizumi, et al. Bioorg Med Chem. 2022 Feb 15;56:116587.