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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Charybdotoxin
Charybdotoxin

Chemical Structure : Charybdotoxin

CAS No.: 95751-30-7

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Charybdotoxin (ChTX;CTX)

货号: PC-60655Not For Human Use, Lab Use Only.

Charybdotoxin (ChTX) selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK).

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100 ug ￥1880 In stock
500 ug ￥2980 In stock
1 mg ￥4780 In stock
5 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Charybdotoxin (ChTX) selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK).
Charybdotoxin produces a concentration-dependent increase in contractility at 10-100 nM in guinea pig smooth muscle tissues.

物理化学性质&存储条件

分子量 4295.89
分子式 C176H277N57O55S7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: 1.0 mg/ml
Chemical Name/SMILES

XFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS (Modifications: X-1 = Glp, Disulfide bridge between 7 - 28, 13 - 33,17 - 35, Ser-37 = C-terminal OH)

参考文献

1. Suarez-Kurtz G, et al. J Pharmacol Exp Ther. 1991 Oct;259(1):439-43.

2. Smith C, et al. J Biol Chem. 1986 Nov 5;261(31):14607-13.

3. Miller C, et al. Nature. 1985 Jan 24-30;313(6000):316-8.

4. Chang CC, et al. Br J Pharmacol. 1983 Jul;79(3):673-80.

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