Ch-319 | Probechem Biochemicals

Chemical Structure : Ch-319

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Ch-319 (Ch319)

货号: PC-35326Not For Human Use, Lab Use Only.

Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.

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1 g		Get quote

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生物&药学活性

Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
Ch-319 reduces viability and induces cell cycle arrest associated with downregulation of PI3K and dephosphorylation of AKT and PRAS40 in PTEN-null PC3M and DU145 PCa cells at 250-500 nM.
Ch-319 decreases tumor weights, reduces expression of androgen receptor, decreases phosphorylation of AKT and PRAS40 and increases FOXO3a in mice.

物理化学性质&存储条件

分子量	604.293
分子式	C33H27NO3Sn
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	triphenylstannyl 2-(benzylcarbamoyl)benzoate

参考文献

1. Durdana Waseem, et al. Abstract 688: Triphenylstannyl 2-(benzylcarbamoyl)benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. AACR.2018.

Ch-319 (Ch319)

生物&药学活性

物理化学性质&存储条件

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Ch-319 (Ch319)

生物&药学活性

物理化学性质&存储条件

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