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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-Cevidoplenib dimesylate
Cevidoplenib dimesylate

Chemical Structure : Cevidoplenib dimesylate

CAS No.: 2043659-93-2

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Cevidoplenib dimesylate (SKI-O-703)

货号: PC-22084Not For Human Use, Lab Use Only.

Cevidoplenib dimesylate (SKI-O-703) is a potent, selective, orally active spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cevidoplenib dimesylate (SKI-O-703) is a potent, selective, orally active spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM.
SKI-O-703 is the orally bioavailable dimesylate salt form of Cevidoplenib (SKI-O-592, Cat#PC-61366).
SKI-O-592 is approximately 9-fold more potent than R406 as a Syk kinase inhibitor.
SKI-O-592 is highly specific for Syk, displays 67- to 2753-fold selectivity against a panel of kinases.
SKI-O-703 significantly ameliorated synovitis, with fewer neutrophils and macrophages infiltrated into the synovial tissue, in model of serum-transferred arthritis.
SKI-O-703 attenuates the progression of autoantibody-mediated autoimmune diseases by inhibiting both autoantibody-producing and autoantibody-sensing cells.

物理化学性质&存储条件

分子量 665.74
分子式 C27H35N7O9S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methanone, cyclopropyl[5-[[4-[4-[[(4S)-4-hydroxy-2-isoxazolidinyl]methyl]-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-1-methyl-1H-indol-3-yl]-, methanesulfonate (1:2)

参考文献

1. Cho S, et al. Clin Exp Immunol. 2023 Mar 8;211(1):31-45.

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