Cevidoplenib (SKI-O-592)

Chemical Structure : Cevidoplenib

CAS No.: 1703788-21-9

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货号: PC-61366Not For Human Use, Lab Use Only.

Cevidoplenib (SKI-O-592) is a potent, selective spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM.

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Cevidoplenib (SKI-O-592) is a potent, selective spleen tyrosine kinase (Syk) inhibitor with IC50 of 6.2 nM.

SKI-O-592 is approximately 9-fold more potent than R406 as a Syk kinase inhibitor.

SKI-O-592 is highly specific for Syk, displays 67- to 2753-fold selectivity against a panel of kinases.

分子量	473.537
分子式	C25H27N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, cyclopropyl[5-[[4-[4-[[(4S)-4-hydroxy-2-isoxazolidinyl]methyl]-3-methyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-1-methyl-1H-indol-3-yl]-

1. Cho S, et al. Clin Exp Immunol. 2023 Mar 8;211(1):31-45.