Cerulenin

Chemical Structure : Cerulenin

CAS No.: 17397-89-6

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货号: PC-70282Not For Human Use, Lab Use Only.

Cerulenin is an antifungal antibiotic that inhibits fatty acid synthase (FASN), also blocks cellular proliferation of KRAS-associated lung cancer cells.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Cerulenin is an antifungal antibiotic that inhibits fatty acid synthase (FASN), also blocks cellular proliferation of KRAS-associated lung cancer cells.
Cerulenin induces pro-survival, Akt and ERK activation, in serum-deprived KRAS mutant cancer cells.
Cerulenin causes a dose-dependent decrease in HER2/neu protein levels in breast cancer cells.

物理化学性质&存储条件

分子量	223.27
分子式	C12H17NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide

参考文献

1. Gouw AM, et al. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4300-4305.

2. Yellen P, et al. Cancer Lett. 2014 Oct 28;353(2):258-63.

3. Menendez JA, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10715-20.

Cerulenin

生物&药学活性

物理化学性质&存储条件

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Cerulenin

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