Ceritinib | ALK inhibitor | Probechem Biochemicals

Chemical Structure : Ceritinib

CAS No.: 1032900-25-6

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Ceritinib (LDK378, LDK-378)

货号: PC-21774Not For Human Use, Lab Use Only.

Ceritinib (LDK378) is a potent, selective and orally active anaplastic lymphoma kinase (ALK) inhibitor with enzymatic IC50 of 200 pM, overcomes crizotinib resistance in NSCLC.

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25 mg	￥980	In stock
50 mg	￥1280	In stock
100 mg	￥1880	In stock
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1 g		Get quote

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生物&药学活性

Ceritinib (LDK378) is a potent, selective and orally active anaplastic lymphoma kinase (ALK) inhibitor with enzymatic IC50 of 200 pM, overcomes crizotinib resistance in NSCLC.
Ceritinib (LDK378) shows high selectivity against an enzyme panel of 30 kinases, with 80-, 70-, and 230-fold for IGF-1R, InsR, and STK22D.
Ceritinib (LDK378) effectively inhibits ALK harboring L1196M, G1269A, I1171T, and S1206Y mutations, does not overcome two crizotinib-resistant ALK mutations, G1202R and F1174C.
Ceritinib (LDK378) overcomes crizotinib resistance in non-small cell lung cancer.

物理化学性质&存储条件

分子量	558.14
分子式	C28H36ClN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

参考文献

1. Marsilje TH, et al. J Med Chem. 2013 Jul 25;56(14):5675-90.

2. Friboulet L, et al. Cancer Discov. 2014 Jun;4(6):662-673.

Ceritinib (LDK378, LDK-378)

生物&药学活性

物理化学性质&存储条件

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Ceritinib (LDK378, LDK-378)

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物理化学性质&存储条件

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