Cercosporamide |CAS:131436-22-1 Probechem Biochemicals

Chemical Structure : Cercosporamide

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Cercosporamide ((-)-Cercosporamide)

货号: PC-45112Not For Human Use, Lab Use Only.

Cercosporamide is a broad-spectrum natural antifungal compound that acts as a selective and highly potent fungal Pkc1 kinase inhibitor, also inhibits Mnk inhibitor with IC50 of 116 nM and 11 nM for Mnk1 and Mnk2, respectively.

规格	价格	库存	数量
500 ug		Get quote
1 mg		Get quote
5 mg		Get quote

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生物&药学活性

Cercosporamide is a broad-spectrum natural antifungal compound that acts as a selective and highly potent fungal Pkc1 kinase inhibitor.
Cercosporamide potently and ATP-competitively inhibits C. albicans Pkc (CaPkc1) kinase with IC50 of <40 nM, Ki of 7 nM.
Cercosporamide shows potent antifungal activity with MIC of 10 ug/ml against both C. albicans and A. fumigatus.
Cercosporamide also is a potent, selective, orally bioavailable Mnk inhibitor with IC50 of 116 nM and 11 nM for Mnk1 and Mnk2, respectively.
Cercosporamide blocks eIF4E phosphorylation in cancer cells, inducing apoptosis, suppressing proliferation, and reducing soft agar colonization.
Cercosporamide is active in tumor xenograft model.

物理化学性质&存储条件

分子量	331.2769
分子式	C16H13NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Dibenzofurancarboxamide, 8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-, (9aS)-

参考文献

1. Sussman A, et al. Eukaryot Cell. 2004 Aug;3(4):932-43.

2. Konicek BW, et al. Cancer Res. 2011 Mar 1;71(5):1849-57.

3. Altman JK, et al. Blood. 2013 May 2;121(18):3675-81.

Cercosporamide ((-)-Cercosporamide)

生物&药学活性

物理化学性质&存储条件

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Cercosporamide ((-)-Cercosporamide)

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物理化学性质&存储条件

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