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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-Celastrol
Celastrol

Chemical Structure : Celastrol

CAS No.: 34157-83-0

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Celastrol (Tripterin)

货号: PC-43371Not For Human Use, Lab Use Only.

Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM.
Celastrol also inhibits 26S proteasome in intact androgen-independent PC-3 and androgen-dependent LNCaP prostate cancer cells at 1-5 uM, induces apoptotic cell death, and accumulates ubiquitinated proteins and natural proteasome substrates, IκB-α, Bax, and p27, and/or suppression of AR protein expression.
Celastrol promotes significant tumor growth inhibition and massive apoptosis induction in vivo.
Celastrol also is a nonselective peroxiredoxin 1 (PRDX1) inhibitor covalently linked to the Cys-173 residue of PRDX1 via a Michael-like addition reaction.

物理化学性质&存储条件

分子量 450.6096
分子式 C29H38O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9.beta.,13.alpha.,14.beta.,20.alpha.)-

参考文献

1. Yang H, et al. Cancer Res. 2006 May 1;66(9):4758-65.

2. Yadav VR, et al. J Mol Med (Berl). 2010 Dec;88(12):1243-53.

3. Chen M, et al. Mol Cancer Res. 2009 Dec;7(12):1946-53.

4. Ge P, et al. Neurol Res. 2010 Feb;32(1):94-100.

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