Cefcapene pivoxil hydrochloride hydrate (Compound 98) is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity, also is a specific small molecule inhibitor of gasdermin D (GSDMD) targeting the GSDMD N-terminal oligomerization interface I (MST KD=0. 32uM), exert pyroptosis inhibitory effects.
Cefcapene pivoxil hydrochloride hydrate (Compound 98) is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity, also is a specific small molecule inhibitor of gasdermin D (GSDMD) targeting the GSDMD N-terminal oligomerization interface I (MST KD=0. 32uM), exert pyroptosis inhibitory effects. Cefcapene pivoxil hydrochloride hydrate significantly inhibited the release of LDH and IL-1β from iBMDM cells primed with LPS. Cefcapene pivoxil hydrochloride hydrate specifically inhibit GSDMD N-terminal oligomerization. Cefcapene pivoxil hydrochloride hydrate does not affect the cytotoxicity induced by GSDME N-terminal fragment and its oligomerization in HEK293T cells. Cefcapene pivoxil hydrochloride hydrate specifically blocks GSDMD-mediated pyroptosis downstream of inflammasome activation. Cefcapene pivoxil hydrochloride hydrate (10 mg/kg) significantly alleviate mouse sepsis in murine model of sepsis. Combination Cefcapene pivoxil hydrochloride hydrate and PD-L1 antibody significantly enhances anti-tumor efficacy.
