Ceefourin-1 | MRP4/ABCC4 inhibitor | Probechem Biochemicals

Chemical Structure : Ceefourin-1

CAS No.: 315702-40-0

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Ceefourin-1 (Ceefourin 1)

货号: PC-20572Not For Human Use, Lab Use Only.

Ceefourin-1 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4/ABCC4), inhibits the efflux of a broad range of MRP4 substrates.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Ceefourin-1 is a highly selective inhibitor of multidrug resistance protein 4 (MRP4/ABCC4), inhibits the efflux of a broad range of MRP4 substrates.
Ceefourin-1 potentiates global cytosolic cAMP accumulation in BE(2)-C neuroblastoma cells following forskolin stimulation.
Ceefourin-1 is relatively non-toxic and well tolerated across a broad range of cell lines with IC50 values typically >50 μM.
Ceefourin-1 reverses 6-MP resistance conferred by MRP4 in HEK293-MRP4 cells, and Ceefourin-1 is more potent than MK-571.
Ceefourin-1 exhibits no activity against cell lines overexpressing P-gp (HEK293-Pgp), ABCG2 (HEK293-ABCG2), and MRP1 (MCF7-VP16).

物理化学性质&存储条件

分子量	294.41
分子式	C11H10N4S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((benzo[d]thiazol-2-ylthio)methyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

参考文献

1. Cheung L, et al. Biochem Pharmacol. 2014 Sep 1;91(1):97-108.

2. Jördens MS, et al. Glia. 2015 Nov;63(11):2092-2105.

Ceefourin-1 (Ceefourin 1)

生物&药学活性

物理化学性质&存储条件

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Ceefourin-1 (Ceefourin 1)

生物&药学活性

物理化学性质&存储条件

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