Ceapin-A7 | ATF6 inhibitor | Probechem Biochemicals

Chemical Structure : Ceapin-A7

CAS No.: 2323027-38-7

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Ceapin-A7 (Ceapin A7)

货号: PC-73217Not For Human Use, Lab Use Only.

Ceapin-A7 is a selective inhibitor of ATF6α with IC50 of 0.59 uM, selective over ATF6β, PERK and other branches of the unfolded protein response (UPR).

规格	价格	库存
5 mg	￥680	In stock
10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2680	In stock
100 mg		Get quote

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生物&药学活性

Ceapin-A7 is a selective inhibitor of ATF6α with IC50 of 0.59 uM, selective over ATF6β, PERK and other branches of the unfolded protein response (UPR).
Ceapin-A7 inhibits ER stress-induced upregulation of BiP in vitro.
Ceapin-A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.
Ceapin-A7 could phenocopy the results obtained using genetic ablation of ATF6α in mouse models.
Ceapin-A7 is a first-in-class series of ATF6α inhibitors that selectively blocks ATF6α and not ATF6β, SREBP or other UPR branches.

物理化学性质&存储条件

分子量	470.33
分子式	C20H12F6N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide

参考文献

1. Ciara M Gallagher, et al. eLife. 2016; 5: e11878.

2. Mufrrih M, et al. mSphere. 2021 Jun 30;6(3):e0036121.

3. Ma M, et al. iScience. 2021 Jun 28;24(7):102791.

Ceapin-A7 (Ceapin A7)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ceapin-A7 (Ceapin A7)

生物&药学活性

物理化学性质&存储条件

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