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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-CeMMEC1
CeMMEC1

Chemical Structure : CeMMEC1

CAS No.: 440662-09-9

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CeMMEC1 (CeMMEC 1)

货号: PC-62289Not For Human Use, Lab Use Only.

CeMMEC1 is a potent, selective second bromodomain of TAF1 inhibitor with Kd of 1.8 uM.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CeMMEC1 is a potent, selective second bromodomain of TAF1 inhibitor with Kd of 1.8 uM.
CeMMEC1 shows high selectivity for the TAF1 (2) bromodomain over BRD4 (1), BRD9, CREBBP, EP300 and TAF1 (2) bromodomains (IC50>10 uM).
CeMMEC1 impaires cell viability in TAF1 downregulated cells.
CeMMEC1 synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.

物理化学性质&存储条件

分子量 336.3
分子式 C19H16N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide

参考文献

1. Sdelci S, et al. Nat Chem Biol. 2016 Jul;12(7):504-10.

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