Cdk5 inhibitor 25-106 | Cdk5/p35 inhibitor | Probechem Biochemicals

Chemical Structure : Cdk5 inhibitor 25-106

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Cdk5 inhibitor 25-106 (Compound 25-106)

货号: PC-47009Not For Human Use, Lab Use Only.

Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM.
Cdk5 inhibitor 25-106 demonstrated similar inhibition against highly homologous Cdk2/Cyclin E (IC50=149 nM), and weak inhibition against CDK9/Cyclin T1 (IC50=5710 nM) in in vitro selectivity assays.
25-106 significantly reduced phospho-Ser549 synapsin I levels in the striatum 2 h after I.V. injection.
25-106 inhibits Cdk5 activity in vivo and displays high potency for inhibition in vitro.
25-106 (50 mg/kg) displayed an increased latency to suspend immobility and displayed a reduction in total immobility time as compared to vehicle-injected mice, modulated behavioral phenotypes linked to Cdk5 through previous characterizations of conditional knockout mice.

物理化学性质&存储条件

分子量	345.399
分子式	C18H23N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(3,4,5-trimethoxyphenyl)acetamide

参考文献

1. Umfress A, et al. Front Pharmacol. 2022 May 12;13:863762.

Cdk5 inhibitor 25-106 (Compound 25-106)

生物&药学活性

物理化学性质&存储条件

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Cdk5 inhibitor 25-106 (Compound 25-106)

生物&药学活性

物理化学性质&存储条件

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