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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Cdc7 inhibitor 7c
Cdc7 inhibitor 7c

Chemical Structure : Cdc7 inhibitor 7c

CAS No.: 1330781-04-8

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Cdc7 inhibitor 7c (Cdc7-IN-7c)

货号: PC-61020Not For Human Use, Lab Use Only.

Cdc7 inhibitor 7c (Cdc7-IN-7c) is a highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cdc7 inhibitor 7c (Cdc7-IN-7c) is a highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively.
Cdc7-IN-7c exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.

物理化学性质&存储条件

分子量 315.395
分子式 C15H17N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(3-methyl-1H-pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

参考文献

1. Kurasawa O, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670.

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