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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-GSK-3-Cazpaullone
Cazpaullone

Chemical Structure : Cazpaullone

CAS No.: 914088-64-5

Cazpaullone (9-Cyano-1-azapaullone)

货号: PC-63152Not For Human Use, Lab Use Only.

Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM).
    Cazpaullone stimulates INS-1E beta cell replication and protects INS-1E cells against glucolipotoxicity induced cell death.
    Cazpaullone also stimulates the replication of primary beta cells in isolated rat islets.

    物理化学性质&存储条件

    分子量 274.283
    分子式 C16H10N4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    6-Oxo-5,6,7,12-tetrahydropyrido(3',2'-2,3)azepino(4,5-b)indole-9-carbonitrile

    参考文献

    1. Stukenbrock H, et al. J Med Chem. 2008 Apr 10;51(7):2196-207.

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