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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-S-nitrosoglutathione reductase (GSNOR)-Cavosonstat
Cavosonstat

Chemical Structure : Cavosonstat

CAS No.: 1371587-51-7

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Cavosonstat (N91115, N-91115)

货号: PC-60035Not For Human Use, Lab Use Only.

Cavosonstat (N91115, N-91115) is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cavosonstat (N91115, N-91115) is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator.
Cavosonstat promotes CFTR maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators.
Cavosonstat significantly increases cell surface expression of F508del-CFTR in vitro combined with CFTR correctors.

物理化学性质&存储条件

分子量 299.71
分子式 C16H10ClNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Chloro-4-(6-hydroxy-2-quinolinyl)benzoic acid

参考文献

1. Donaldson SH, et al. J Cyst Fibros. 2017 May;16(3):371-379.

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