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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-Cariporide
Cariporide

Chemical Structure : Cariporide

CAS No.: 159138-80-4

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Cariporide (HOE642, HOE-642)

货号: PC-35052Not For Human Use, Lab Use Only.

Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM).

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25 mg ￥1380 In stock
50 mg ￥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM).
Cariporide (HOE642) inhibits the amiloride sensitive sodium influx in rabbit erythrocytes, reduces the swelling of human platelets induced by intracellular acidification, and delays pH recovery in rat cardiomyocytes.
Cariporide (HOE642) reduces and prevents ventricular premature beats, ventricular tachycardia, and ventricular fibrillation after oral treatment in vivo.
Cariporide (HOE642) shows cardioprotective and antiarrhythmic effects in ischaemic and reperfused hearts.

物理化学性质&存储条件

分子量 283.346
分子式 C12H17N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide

参考文献

1. Scholz W, et al. Cardiovasc Res. 1995 Feb;29(2):260-8.

2. Russ U, et al. Pflugers Arch. 1996 Nov-Dec;433(1-2):26-34.

3. Xue YX, et al. Eur J Pharmacol. 1996 Dec 19;317(2-3):309-16.

4. Aye NN, et al. Eur J Pharmacol. 1997 Nov 27;339(2-3):121-7.

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