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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-Capzimin
Capzimin

Chemical Structure : Capzimin

CAS No.: 2084868-04-0

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Capzimin (Rpn11 inhibitor 35)

货号: PC-61132Not For Human Use, Lab Use Only.

Capzimin is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Capzimin is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH.
Capzimin inhibits 293T and A549 cells proliferation with IC50 of 2.1 and 3.8 uM, respectively.

物理化学性质&存储条件

分子量 628.802
分子式 C30H24N6O2S4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8,8'-disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)

参考文献

1. Perez C, et al. J Med Chem. 2017 Feb 23;60(4):1343-1361.

2. Li J, et al. Nat Chem Biol. 2017 May;13(5):486-493.

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