Capsazepine

Chemical Structure : Capsazepine

CAS No.: 138977-28-3

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货号: PC-22981Not For Human Use, Lab Use Only.

Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM.

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Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM.
Capsazepine inhibited [(3)H]RTX binding to HEK293/VR1 cells with a K(i) value of 6.2 microM and binding to DRG membranes with a K(i) value of 8.6 microM.
Capsazepine induces ROS generation and ROS mediate Capsazepine-induced DR5 upregulation in HCT116 cells.

物理化学性质&存储条件

分子量	376.90
分子式	C19H21ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

参考文献

1. Szallasi A, et al. Mol Pharmacol. 1999 Sep;56(3):581-7.

2. Smart D, et al. Br J Pharmacol. 2000 Jan;129(2):227-30.

3. Trevisani M, et al. Nat Neurosci. 2002 Jun;5(6):546-51.

Capsazepine

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