Cap5-IN-1

Chemical Structure : Cap5-IN-1

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货号: PC-27116Not For Human Use, Lab Use Only.

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生物&药学活性

Cap5-IN-1 is a competitive, cellulo active inhibitor of bacterial cyclic oligonucleotide-based anti-phage signaling system (CBASS) effector nuclease Cap5, effectively blocks phage defenses in bacteria.
Cap5 is hypothesized to degrade genomic DNA in virally infected cells, leading to cell dearth through abortive infection.
Cap5-IN-1 inhibitscGAMP-activated nuclease activity of L. lactis Cap5 (LlCap5) with IC50 of 120 uM.
Cap5-IN-1 also inhibits PsCap5 from the plant pathogen Pseudomonas syringae with IC50 of 24 uM.
Cap5-IN-1 does not inhibit two unrelated restriction endonucleases XhoI and DpnI, as well as Cas9, an endonuclease that contains an HNH catalytic domain.
Cap5-IN-1 can enter the cytosol of Gram-negative bacteria and inhibits the activation of PsCap5.
Cap5-IN-1 promotes phage infection in CBASS-containing bacteria.

物理化学性质&存储条件

分子量	536.59
分子式	C31H28N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((1-(2-((furan-2-ylmethyl)amino)-2-oxoethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)-N-(4-methylbenzyl)benzamide

参考文献

1. Zhang C, et al. iScience. 2026 Jun 1;29(6):116174.

Cap5-IN-1

生物&药学活性

物理化学性质&存储条件

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Cap5-IN-1

生物&药学活性

物理化学性质&存储条件

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