Cantrixil | CAS 2135511-22-5 | Probechem Biochemicals

Chemical Structure : Cantrixil

加入收藏

Cantrixil (TRX-E-002-1)

货号: PC-20927Not For Human Use, Lab Use Only.

Cantrixil (TRX-E-002-1) is a potent inducer of CD44+/MyD88+ ovarian cancer stem cell (OCSC) death with IC50 of 47 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Cantrixil (TRX-E-002-1) is a potent inducer of CD44+/MyD88+ ovarian cancer stem cell (OCSC) death with IC50 of 47 nM.
Cantrixil (TRX-E-002-1) induces cell death by the activation and enhanced expression of c-Jun, leading to the induction of caspases.
Cantrixil (TRX-E-002-1) is effective against both clones and was able to decrease the percentage of viable cells with IC50 of 68 nmol/L and 27 nmol/L for chemosensitive ovarian cancer cells (OCC1 and OCC2) respectively.
TRX-E-002-1 is effective in inducing death in 3D ovarian cancer spheroids, prevents OCSC recurrence in vitro.
TRX-E-002-1-induced cell death is associated with phosphorylation and increased expression levels of c-Jun, activates the caspase cascade and requires c-Jun activation.
TRX-E-002-1 (100 mg/kg daily, i.p.) demonstrates significant antitumor activity against both primary and recurrent disease in a mouse xenograft model of ovarian cancer.
The combination of TRX-E-002-1 and cisplatin is able to decrease tumor kinetics better than monotherapy.

物理化学性质&存储条件

分子量	408.45
分子式	C24H24O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	OC1=CC=C2[C@H](C3=CC=C(O)C=C3)[C@H](C4=CC(OC)=C(O)C(OC)=C4)COC2=C1C

参考文献

1. Alvero AB, et al. Mol Cancer Ther. 2016 Jun;15(6):1279-90.

2. Saif MW, et al. Cancer Chemother Pharmacol. 2017 Feb;79(2):303-314.

Cantrixil (TRX-E-002-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Cantrixil (TRX-E-002-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.