Canagliflozin |CAS:842133-18-0 Probechem Biochemicals

Chemical Structure : Canagliflozin

CAS No.: 842133-18-0

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Canagliflozin (JNJ 24831754ZAE;JNJ 28431754;JNJ 28431754AAA;TA 7284)

货号: PC-42594Not For Human Use, Lab Use Only.

Canagliflozin (JNJ 28431754) is a highly potent and selective SGLT2 inhibitor with IC50 of 4.4, 3.7 and 2.0 nM for hSGLT2, rSGLT2 and mSGLT2, respectively.

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25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg	￥4580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Canagliflozin (JNJ 28431754) is a highly potent and selective SGLT2 inhibitor with IC50 of 4.4, 3.7 and 2.0 nM for hSGLT2, rSGLT2 and mSGLT2, respectively.
Canagliflozin (JNJ 28431754) displays >100-fold selectivity over SGLT1.
Canagliflozin (JNJ 28431754) improves glycemic control and beta-cell function in rodent models of T2DM, and reduces body weight gain in rodent models of obesity.

物理化学性质&存储条件

分子量	444.5157
分子式	C24H25FO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-

参考文献

1. Nomura S, et al. J Med Chem. 2010 Sep 9;53(17):6355-60.

2. Rosenstock J, et al. Diabetes Care. 2012 Jun;35(6):1232-8.

3. Liang Y, et al. PLoS One. 2012;7(2):e30555.

Canagliflozin (JNJ 24831754ZAE;JNJ 28431754;JNJ 28431754AAA;TA 7284)

生物&药学活性

物理化学性质&存储条件

参考文献

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Canagliflozin (JNJ 24831754ZAE;JNJ 28431754;JNJ 28431754AAA;TA 7284)

生物&药学活性

物理化学性质&存储条件

参考文献

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