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Calycosin

Chemical Structure : Calycosin

CAS No.: 20575-57-9

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Calycosin (Cyclosin)

货号: PC-24316Not For Human Use, Lab Use Only.

Calycosin is a flavonoid compound derived from the root of Astragalus, alleviates ischemic stroke by inhibiting PANoptosis.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
50 mg ￥2780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Calycosin is a flavonoid compound derived from the root of Astragalus, alleviates ischemic stroke by inhibiting PANoptosis.
Calycosin has significant effects in various biological activities, including anti-inflammatory, antioxidation, antitumor, improving cardiovascular health, regulating metabolism, and enhancing immune function, especially in the nervous system.
Calycosin could improve the cell growth of HT22, leading to enhanced cell viability, reduced lactate dehydrogenase leakage, and decreased cell apoptosis after OGD/R.
Calycosin also regulates the expression of PANoptosis-related genes such as NLRP3, GSDMD, MLKL, and RIPK1 and increases the Bcl-2/Bax ratio, effectively reducing cellular damage and providing protection.
PANoptosis is a newly identified form of cell death that encompasses pyroptosis, apoptosis, and necroptosis.

物理化学性质&存储条件

分子量 284.27
分子式 C16H12O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one

参考文献

1. Huiyan An, et al. ACS Chem Neurosci. 2025 Mar 29. doi: 10.1021/acschemneuro.5c00072.

2. Zhou Y, et al. Tumour Biol. 2015 Feb 12.

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