Calmodulin inhibitor W-7 | Calmodulin antagonist | Probechem Biochemicals

Chemical Structure : Calmodulin inhibitor W-7

CAS No.: 61714-27-0

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Calmodulin inhibitor W-7 (W-7 hydrochloride)

货号: PC-23469Not For Human Use, Lab Use Only.

W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively.

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10 mg	￥680	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
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生物&药学活性

W-7 hydrochloride is a selective calmodulin antagonist, inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase (MLCK) with IC50 of 28 μM and 51 µM, respectively.
W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle.
Treatment with W-7 results in the dose-dependent inhibition of cell proliferation in various human multiple myeloma cell lines.
W-7 induces G1 phase cell cycle arrest by downregulating cyclins and upregulating p21cip1. W-7 induces apoptosis via caspase activation.

物理化学性质&存储条件

分子量	377.32
分子式	C16H22Cl2N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Aminohexyl)-5-chloronaphthalene-1-sulfonamide hydrochloride

参考文献

1. H Hidaka, et al. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4354-7.

2. M Asano. J Pharmacol Exp Ther. 1989 Nov;251(2):764-73.

Calmodulin inhibitor W-7 (W-7 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Calmodulin inhibitor W-7 (W-7 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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