Calicheamicin |CAS:108212-75-5 Probechem Biochemicals

Chemical Structure : Calicheamicin

CAS No.: 108212-75-5

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Calicheamicin (Calicheamicin γ1)

货号: PC-45655Not For Human Use, Lab Use Only.

Calicheamicin γ1 is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission.

规格	价格	库存	数量
5 mg	￥6800	In stock
10 mg	￥12000	In stock

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生物&药学活性

Calicheamicin γ1 is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission; ADC payload used in development of antibody drug conjugates.

物理化学性质&存储条件

分子量	1368.348
分子式	C55H74IN3O21S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-α-L-threo-pento

参考文献

1. Lambert JM, et al. Adv Ther. 2017 May;34(5):1015-1035.

2. Guffroy M, et al. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770.

3. Damelin M, et al. Clin Cancer Res. 2015 Sep 15;21(18):4165-73.

Calicheamicin (Calicheamicin γ1)

生物&药学活性

物理化学性质&存储条件

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Calicheamicin (Calicheamicin γ1)

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