Calicheamicin (Calicheamicin γ1)

Chemical Structure : Calicheamicin

CAS No.: 108212-75-5

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货号: PC-45655Not For Human Use, Lab Use Only.

Calicheamicin (Calicheamicin γ1) is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission, an ADC payload used in development of antibody drug conjugates.

规格	价格	库存
1 mg	￥2480	In stock
5 mg	￥4780	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

Calicheamicin (Calicheamicin γ1) is an enediyne antitumor antibiotic that acts by binding to DNA and causes strand scission, an ADC payload used in development of antibody drug conjugates.

物理化学性质&存储条件

分子量	1368.348
分子式	C55H74IN3O21S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-[(1R,4Z,8S,13E)-8-[[4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-2-O-[2,4-dideoxy-4-(ethylamino)-3-O-methyl-α-L-threo-pento

参考文献

1. Lambert JM, et al. Adv Ther. 2017 May;34(5):1015-1035.

2. Guffroy M, et al. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770.

3. Damelin M, et al. Clin Cancer Res. 2015 Sep 15;21(18):4165-73.