Cabozantinib (S-malate) |CAS:1140909-48-3 Probechem Biochemicals

Chemical Structure : Cabozantinib (S-malate)

CAS No.: 1140909-48-3

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Cabozantinib (S-malate) (XL184;XL-184;Cabozantinib;XL 184)

货号: PC-42859Not For Human Use, Lab Use Only.

Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

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25 mg	￥550	In stock
100 mg	￥1350	In stock
250 mg	￥2250	In stock
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生物&药学活性

Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively; eliminates tumor vasculature, reduces pericytes and empty basement membrane sleeves, causes widespread intratumoral hypoxia and tumor cell apoptosis, and slows regrowth of the tumor vasculature, also decreases invasiveness of primary tumors and reduces metastasis in pancreatic islet cancer; exerts marked anti-MPNST effects in vitro and in vivo.

Kidney Cancer

Approved

物理化学性质&存储条件

分子量	635.5931
分子式	C32H30FN3O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 23 mg/mL
Chemical Name/SMILES	Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

参考文献

1. You WK, et al. Cancer Res. 2011 Jul 15;71(14):4758-68.

2. Durante C, et al. Expert Opin Investig Drugs. 2011 Mar;20(3):407-413.

3. Torres KE, et al. Clin Cancer Res. 2011 Jun 15;17(12):3943-55.

4. Kurzrock R, et al. J Clin Oncol. 2011 Jul 1;29(19):2660-6.

Cabozantinib (S-malate) (XL184;XL-184;Cabozantinib;XL 184)

生物&药学活性

物理化学性质&存储条件

参考文献

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Cabozantinib (S-malate) (XL184;XL-184;Cabozantinib;XL 184)

生物&药学活性

物理化学性质&存储条件

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