CZL-S092

Chemical Structure : CZL-S092

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货号: PC-24920Not For Human Use, Lab Use Only.

CZL-S092 is a potent, selective PLK4 inhibitor with IC50 of 0.9 nM.

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100 mg		Get quote

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生物&药学活性

CZL-S092 is a potent, selective PLK4 inhibitor with IC50 of 0.9 nM.
CZL-S092 exhibitspotent antiproliferative activity against MCF-7, IMR-32 and SH-SY5Y cells with IC50 values of 2.828 μM, 1.143 μM, and 1.329 μM, respectively.
CZL-S092 exhibits excellent selectivity over other PLK family members (PLK1, PLK2, and PLK3).
CZL-S092 exhibits concentration-dependent inhibition of MCF-7 colony formation, inhibits growth of MCF-7 cancer cells at a concentration of 1.0 μM and almost completely inhibits at a concentration of 2.5 μM.
CZL-S092 (5 uM) effectively inhibited IMR-32 cell migration.
CZL-S092 displays good pharmacokinetic properties (Rats, F = 22.1 %).

物理化学性质&存储条件

分子量	418.49
分子式	C23H19FN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(3-fluorophenyl)-N-methyl-2-((3-(2-(pyridin-3-yl)vinyl)-1H-indazol-6-yl)thio)acetamide

参考文献

1. Liu N, et al. Eur J Med Chem. 2025 Jun 13;296:117867.

CZL-S092

生物&药学活性

物理化学性质&存储条件

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CZL-S092

生物&药学活性

物理化学性质&存储条件

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