CZL-077 | p300/CBP inhibitor | Probechem Biochemicals

Chemical Structure : CZL-077

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CZL-077 (CZL077)

货号: PC-25946Not For Human Use, Lab Use Only.

CZL-077 is a potent, selective and orally active p300/CBP bromodomain inhibitor with IC50 of 34 nM and 52 nM respectively, selective over BRD4 BD1 and BD2.

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生物&药学活性

CZL-077 is a potent, selective and orally active p300/CBP bromodomain inhibitor with IC50 of 34 nM and 52 nM respectively, selective over BRD4 BD1 and BD2.
CZL-077 effectively inhibits cell growth with IC50 values of 0.024 μM and 5.6 μM in OPM-2 and 22RV1 cells, respectively.
CZL-077 exhibits high selectivity over the BRDs of BET proteins.
CZL-077 shows potent in vivo efficacy in the OPM-2 xenograft model and demonstrates more potent antitumor activity in the 22RV1 xenograft model, with tumor growth inhibition values of 56.2% and 72.8%, respectively

物理化学性质&存储条件

分子量	577.63
分子式	C30H26F3N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5S)-1-(3,4-difluorophenyl)-5-(5-(3,5-dimethylisoxazol-4-yl)-1-((R)-2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-1H-benzo[d]imidazol-2-yl)-3-fluoropyrrolidin-2-one

参考文献

1. Chen Z, et al. Eur J Med Chem. 2025 Dec 16;304:118489.

CZL-077 (CZL077)

生物&药学活性

物理化学性质&存储条件

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CZL-077 (CZL077)

生物&药学活性

物理化学性质&存储条件

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