CZ-48 | SARM1 activator | Probechem Biochemicals

Chemical Structure : CZ-48

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CZ-48 (Sulfo-ara-F-NMN)

货号: PC-26389Not For Human Use, Lab Use Only.

CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38.

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生物&药学活性

CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38.
CZ-48 induced increase in the cADPR levels in SARM1-expressing cells.
CZ-48 activates SARM1 via a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain.
CZ-48 mimics cellular NMN in activating SARM1 enzymatically.
CZ-48 elevates cADPR, depletes NAD and ATP, and induces non-apoptotic death in SARM1-overexpressing cells.

物理化学性质&存储条件

分子量	352.27
分子式	C11H14FN2O6PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O-(((2R,3R,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl) S-hydrogen phosphorothioate

参考文献

1. Zhao ZY, et al. iScience. 2019 May 31;15:452-466.

CZ-48 (Sulfo-ara-F-NMN)

生物&药学活性

物理化学性质&存储条件

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CZ-48 (Sulfo-ara-F-NMN)

生物&药学活性

物理化学性质&存储条件

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