CZ-2401 | TRIM47-HNF4α inhibitor | Probechem Biochemicals

Chemical Structure : CZ-2401

加入收藏

CZ-2401 (CZ2401)

货号: PC-26272Not For Human Use, Lab Use Only.

CZ-2401 is a potent, specific inhibitor of the TRIM47-HNF4α interaction, binds to HNF4α with MST Kd of 2.52 uM, stabilizes HNF4α protein and activates HNF4α transcriptional activity.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CZ-2401 is a potent, specific inhibitor of the TRIM47-HNF4α interaction, binds to HNF4α with MST Kd of 2.52 uM, stabilizes HNF4α protein and activates HNF4α transcriptional activity.
CZ-2401 enhances HNF4α stability by blocking HNF4α–TRIM47 interaction.
CZ-2401 exhibits potent cytotoxic effects in both Huh7 and Hep3B cells but a minimal cytotoxicity in HEK293T cells with absent HNF4α expression.
HNF4α knockdown in Huh7 and Hep3B cells substantially attenuated CZ-2401-induced cytotoxicity, confirming that CZ-2401 specifically targets HNF4α.
CZ-2401 (8 mg/kg, i.p.; Vehicle: saline solution) ameliorates the TRIM47-driven HCC progression in mouse xenograft model by subcutaneously inoculating nude mice with Hep3B cells.

物理化学性质&存储条件

分子量	421.53
分子式	C18H23N5O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-(3-cyclohexylureido)-1,3,4-thiadiazol-2-yl)thio)-N-(3-methoxyphenyl)acetamide

参考文献

1. Hong H, et al. Acta Pharm Sin B. 2026 Feb;16(2):913-929.

CZ-2401 (CZ2401)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CZ-2401 (CZ2401)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.