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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-CYT387 sulfate
CYT387 sulfate

Chemical Structure : CYT387 sulfate

CAS No.: 1056636-06-6

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CYT387 sulfate (CYT-387 sulfate, Momelotinib sulfate)

货号: PC-42752Not For Human Use, Lab Use Only.

Momelotinib (CYT387) sulfate is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥2980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Momelotinib (CYT387) sulfate is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
Momelotinib shows significantly less activity against other kinases, including JAK3 (IC50=155 nM).
Momelotinib inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM.
Momelotinib inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).

物理化学性质&存储条件

分子量 610.6168
分子式 C23H26N6O10S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 6.1 mg/mL
Chemical Name/SMILES

Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, sulfate (1:2)

参考文献

1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.

2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.

3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.

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