CYT387 mesylate |CAS:1056636-07-7 Probechem Biochemicals

Chemical Structure : CYT387 mesylate

CAS No.: 1056636-07-7

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CYT387 mesylate (CYT 387 mesylate;CYT-387 mesylate;Momelotinib mesylate)

货号: PC-42753Not For Human Use, Lab Use Only.

A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.

规格	价格	库存
10 mg	￥840	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock

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生物&药学活性

A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM; shows significantly less activity against other kinases, including JAK3 (IC50=155 nM); inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM; inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).

Bone Cancer

Phase 3 Clinical

物理化学性质&存储条件

分子量	510.5654
分子式	C24H26N6O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, methanesulfonate (1:x)

参考文献

1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.

2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.

3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.

CYT387 mesylate (CYT 387 mesylate;CYT-387 mesylate;Momelotinib mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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CYT387 mesylate (CYT 387 mesylate;CYT-387 mesylate;Momelotinib mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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