Chemical Structure : CYT387
CAS No.: 1056634-68-4
货号: PC-42751Not For Human Use, Lab Use Only.
Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥780 | In stock | |
25 mg | ¥1280 | In stock | |
50 mg | ¥1780 | In stock | |
100 mg | Get quote |
大包装,大折扣!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
Momelotinib (CYT387) shows significantly less activity against other kinases, including JAK3 (IC50=155 nM).
Momelotinib (CYT387) inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM.
Momelotinib (CYT387) inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).
分子量 | 414.4598 | |
分子式 | C23H22N6O2 | |
外观性状 | Solid | |
储存条件 |
|
|
Solubility |
DMSO: ≥ 40 mg/mL |
|
Chemical Name/SMILES |
Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]- |
1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.
2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.
3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.
备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright