CYP4A11 and CYP4F2 inhibitor 15

Chemical Structure : CYP4A11 and CYP4F2 inhibitor 15

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货号: PC-23328Not For Human Use, Lab Use Only.

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生物&药学活性

CYP4A11 and CYP4F2 inhibitor 15 is a potent, dual inhibitor of cytochrome P450 (CYP) 4F2 and CYP4A11 (CYP4A11/4F2) with IC50 of 120/220 nM respectively, exhibits potent suppression of 20-HETE production in both human and rat renal microsomes with IC50 of 18 nM and 37 nM.
CYP4A11/4F2 inhibitor 15 displays high selectivity over CYP4F22 (IC50=2900 nM).
CYP4A11/4F2 inhibitor 15 does not inhibit ω-hydroxylation of ULCFAs in human keratinocytes.
CYP4A11/4F2 inhibitor 15 significantly inhibited renal 20-HETE production after oral administration.

物理化学性质&存储条件

分子量	361.44
分子式	C19H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-2-[(7-{[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxy}heptyl)oxy]propanoic acid

参考文献

1. Madoka Kawamura, et al. Bioorg Med Chem. 2023 Oct 18:95:117505.