CYP1B1 inhibitor TMS |CAS 24144-92-1 Probechem Biochemicals

Chemical Structure : CYP1B1 inhibitor TMS

CAS No.: 24144-92-1

加入收藏

CYP1B1 inhibitor TMS (2,4,3',5'-tetramethoxystilbene, TMS)

货号: PC-45614Not For Human Use, Lab Use Only.

TMS is a potent and selective inhibitor of the EROD activity of P450 1B1 (CYP1B1) with IC50 of 6 nM

规格	价格	库存
10 mg	￥680	In stock
25 mg	￥1180	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TMS is a potent and selective inhibitor of the EROD activity of P450 1B1 (CYP1B1) with IC50 of 6 nM.
TMS exhibits 50-fold selectivity for P450 1B1 over P450 1A1 (IC50=300 nM) and 500-fold selectivity for P450 1B1 over P450 1A2 (IC50=3 uM).
TMS blocks the conversion of estradiol to 4-OH-estradiol, inhibits tubulin polymerization and microtubule formation, causes cell cycle block at the G2-M phase, and induces apoptosis.
TMS significantly attenuates hypoxic PAH and hypoxic+SU5416 PAH in vivo (3mg/kg, i.p.).

物理化学性质&存储条件

分子量	300.349
分子式	C18H20O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzene, 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-

参考文献

1. Chun YJ, et al. Cancer Res. 2001 Nov 15;61(22):8164-70.

2. Park H, et al. Cancer Res. 2007 Jun 15;67(12):5717-26.

3. White K, et al. Circulation. 2012 Aug 28;126(9):1087-98.

CYP1B1 inhibitor TMS (2,4,3',5'-tetramethoxystilbene, TMS)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CYP1B1 inhibitor TMS (2,4,3',5'-tetramethoxystilbene, TMS)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.