CYP11B1-IN-25 |CAS:2101952-78-5 Probechem Biochemicals

Chemical Structure : CYP11B1-IN-25

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CYP11B1-IN-25 (CYP11B1 Inhibitor C25)

货号: PC-61692Not For Human Use, Lab Use Only.

CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.

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生物&药学活性

CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.
CYP11B1-IN-25 inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM.
CYP11B1-IN-25 shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.

物理化学性质&存储条件

分子量	266.3
分子式	C16H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-methoxypyridin-3-yl)methyl)-3-phenylisoxazole

参考文献

1. Emmerich J, et al. J Med Chem. 2017 Jun 22;60(12):5086-5098.

CYP11B1-IN-25 (CYP11B1 Inhibitor C25)

生物&药学活性

物理化学性质&存储条件

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CYP11B1-IN-25 (CYP11B1 Inhibitor C25)

生物&药学活性

物理化学性质&存储条件

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