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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-CYH33 methanesulfonate
CYH33 methanesulfonate

Chemical Structure : CYH33 methanesulfonate

CAS No.: 1494684-33-1

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CYH33 methanesulfonate (Risovalisib methanesulfonate;HH-CYH33)

货号: PC-35740Not For Human Use, Lab Use Only.

CYH33 (Risovalisib) methanesulfonate is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CYH33 (Risovalisib) methanesulfonate is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.
    CYH33 (Risovalisib) also displays little to no activity against more than 300 kinases.
    CYH33 (Risovalisib) inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.
    CYH33 (Risovalisib) shows significant efficacy to inhibit the growth of SKOV-3 xenograft.

    物理化学性质&存储条件

    分子量 694.702
    分子式 C25H33F3N8O8S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate methanesulfonate

    参考文献

    1. Haoyue Xiang, et al. Abstract LB-268, AACR, 2018.

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