CYH33 |CAS:1494684-28-4 Probechem Biochemicals

Chemical Structure : CYH33

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CYH33 (Risovalisib, CYH-33)

货号: PC-35739Not For Human Use, Lab Use Only.

CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.

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生物&药学活性

CYH33 (Risovalisib) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.
CYH33 (Risovalisib) also displays little to no activity against more than 300 kinases.
CYH33 (Risovalisib) inhibits PI3K/AKT/mTOR signaling in glioblastoma U87MG and rhabdomyosarcoma Rh30 cells, shows potent anti-proliferative activity in against cell proliferation in a panel cancer cell lines originated from breast, lung, ovary and colon, prostate etc.
CYH33 (Risovalisib) shows significant efficacy to inhibit the growth of SKOV-3 xenograft.

物理化学性质&存储条件

分子量	598.602
分子式	C24H29F3N8O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate

参考文献

1. Haoyue Xiang, et al. Abstract LB-268, AACR, 2018.

CYH33 (Risovalisib, CYH-33)

生物&药学活性

物理化学性质&存储条件

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CYH33 (Risovalisib, CYH-33)

生物&药学活性

物理化学性质&存储条件

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