CYD19 |CAS:2415281-52-4 Probechem Biochemicals

Chemical Structure : CYD19

CAS No.: 2415281-52-4

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CYD19 (Snail inhibitor CYD19)

货号: PC-38205Not For Human Use, Lab Use Only.

Snail inhibitor CYD19 (CYD19) is a small-molecule compound that binds to the zinc finger transcription factor Snail (Kd=0.18 uM), and disrupts Snail interaction with CBP/p300.

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5 mg	￥2280	In stock
10 mg	￥3780	In stock
25 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

Snail inhibitor CYD19 (CYD19) is a small-molecule compound that binds to the zinc finger transcription factor Snail (Kd=0.18 uM), and disrupts Snail interaction with CBP/p300.
Snail inhibitor CYD19 impairs CBP/p300-mediated Snail acetylation and then promotes its degradation through the ubiquitin-proteasome pathway in aggressive cancer cells.
CYD19 restores Snail-dependent repression of wild-type p53, thus reducing tumor growth and survival in vitro and in vivo.

物理化学性质&存储条件

分子量	488.545
分子式	C24H21FN8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-amino-4-fluorophenyl)-4-(((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)methyl)benzamide

参考文献

1. Hong-Mei Li, et al. Sci Adv. 2020 Apr 22;6(17):eaaw8500.

CYD19 (Snail inhibitor CYD19)

生物&药学活性

物理化学性质&存储条件

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CYD19 (Snail inhibitor CYD19)

生物&药学活性

物理化学性质&存储条件

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