CYD-4-61

Chemical Structure : CYD-4-61

CAS No.: 1425944-33-7

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货号: PC-27545Not For Human Use, Lab Use Only.

CYD-4-61 is a small molecule Bax activator, exhibits potent antiproliferative activity with IC50 of 0.07 uM against triple-negative breast cancer MDA-MB-231 and 0.06 uM against ER-positive breast cancer MCF-7 cell lines, respectively.

规格	价格	库存
5 mg	￥2380	In stock
10 mg	￥3880	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CYD-4-61 is a small molecule Bax activator, exhibits potent antiproliferative activity with IC50 of 0.07 uM against triple-negative breast cancer MDA-MB-231 and 0.06 uM against ER-positive breast cancer MCF-7 cell lines, respectively.
CYD-4-61 (1 uM) inhibits colony formation and induces apoptosis induction in breast cancer cells.
CYD-4-61 causes induction of active Bax protein to trigger the intrinsic apoptotic signaling pathway.
CYD-4-61 significantly suppressed breast cancer xenograft tumor growth in vivo.
CYD-4-61 potently inhibits tumor cell proliferation, induces apoptosis, and suppresses cancer stem cell-like properties, with enhanced activity in radiation-resistant gastric adenocarcinoma (GAC) cells.

物理化学性质&存储条件

分子量	359.39
分子式	C21H17N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-((2-nitro-9H-fluoren-9-ylidene)methyl)pyridin-2-yl)oxy)ethan-1-amine

参考文献

1. Liu G, et al. Eur J Med Chem. 2019 Sep 15;178:589-605.

2. Zou G, et al. Cancer Lett. 2026 Aug 7:218777.

CYD-4-61

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物理化学性质&存储条件

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CYD-4-61

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